Acetic Anhydride → HCID 178474375, compound

HRID 1609129Notes

Reaction equation

HRID 1609129 reaction equation
[NH2:1][C:2]1[C:3]([CH3:28])=[N:4][C:5]([CH3:27])=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]2[NH:26][N:25]=[N:24][N:23]=2)=[CH:12][CH:11]=1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>N1C=CC=CC=1>[C:29]([NH:1][C:2]1[C:3]([CH3:28])=[N:4][C:5]([CH3:27])=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]2[NH:26][N:25]=[N:24][N:23]=2)=[CH:14][CH:15]=1)(=[O:31])[CH3:30]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178428936HCID 178428936, compound

Product 1

HCID 178474375HCID 178474375, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 100 mg of the compound obtained in Example 69 placed in 2 ml of pyridine was added 1 ml of acetic anhydride, followed by stirring at 60° C. for three hours. After the reaction was completed, the reaction mixture was concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (8 g, chloroform:methanol=2:1), whereby 95 mg of a colorless powder of the title compound was obtained (yield: 86%).

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by a silica gel column chromatography (8 g, chloroform:methanol=2:1), whereby 95 mg of a colorless powder of the title compound
  3. customwas obtained (yield: 86%)

Sources & evidence

ORD record
ord-6a1caef433ed4c5caa9586d319506f2a
Source dataset
uspto-grants-1995_03
Patent number
US05399566

Reaction notes

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