Trifluoroacetic acid → 7-(3-Aminopropoxy)-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline

HRID 160918Notes

Reaction equation

HRID 160918 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:33])[c:5]([O:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:20][CH2:21][CH2:22][NH:23][C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:31][cH:32]1.[OH:34][C:35]([C:36]([F:37])([F:38])[F:39])=[O:40]>>[Br:1][c:2]1[cH:3][c:4]([F:33])[c:5]([O:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:20][CH2:21][CH2:22][NH2:23])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:31][cH:32]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 220306804-(4-Bromo-2-fluorophenoxy)-7-(3-(N-tertbutoxycarbonylamino)propoxy)-6-methoxyquinazoline

Product 1

HCID 220308707-(3-Aminopropoxy)-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline

Sources & evidence

ORD record
ord-1965fefcbafa47bda98cf6fb2cb4705a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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