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HRID1609185

反应详情

EQUATION

反应方程式

HRID 1609185 的结构方程式

REACTANTS

反应物

2
结构：CCCCC(=O)Cl
HCID61186

Valeryl chloride

C5H9ClO

结构：COC(=O)[C@@H](NCc1ccc(-c2ccccc2C#N)cc1)C(C)C
HCID16744794

Methyl N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-L-valinate

C20H22N2O2

PRODUCTS

生成物

1
结构：CCCCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)[C@H](C(=O)OC)C(C)C
HCID16744795

N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine methyl ester

C25H30N2O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Reaction of 1.15 g of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester, 0.625 ml of triethylamine and 0.56 ml of n-valeryl chloride analogously to Example 1c) yields N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester after flash chromatography (N3). (TLC: N2) Rf : 0.63.