Butyryl chloride → HCID 54509784, compound

HRID 1609186Notes

Reaction equation

HRID 1609186 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C@H:4]([CH3:21])[NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1.[CH3:23][CH2:24][CH2:25][C:26](Cl)=[O:27]>C(N(CC)CC)C>[CH3:1][O:2][C:3](=[O:22])[C@H:4]([CH3:21])[N:5]([C:26](=[O:27])[CH2:25][CH2:24][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 8855Butyryl chlorideHCID 22852211HCID 22852211, compound

Product 1

HCID 54509784HCID 54509784, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The starting material can be obtained, for example, analogously to Example 2: Reaction of 2.0 g of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-alanine methyl ester, 1.23 ml of triethylamine and 0.92 ml of n-butyryl chloride yields N-butyryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-alanine methyl ester. (TLC: N2) Rf : 0.5.

Sources & evidence

ORD record
ord-15e002995057449b9f9b52439646b56f
Source dataset
uspto-grants-1995_03
Patent number
US05399578

Reaction notes

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