Ethyl Acetate → HCID 178447283, compound

HRID 1609211Notes

Reaction equation

HRID 1609211 reaction equation
C([O:8][C:9]([C:11]1([N:17]([C:36](=[O:41])[CH2:37][CH2:38][CH2:39][CH3:40])[CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[NH:35][N:34]=[N:33][N:32]=3)=[CH:21][CH:20]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10])C1C=CC=CC=1.C(OCC)(=O)C>O1CCOCC1.[Pd]>[C:9]([C:11]1([N:17]([C:36](=[O:41])[CH2:37][CH2:38][CH2:39][CH3:40])[CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[NH:32][N:33]=[N:34][N:35]=3)=[CH:21][CH:20]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)([OH:10])=[O:8]

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 178447281HCID 178447281, compound

Product 1

HCID 178447283HCID 178447283, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

A solution of 2.4 g (4.3 mmol) of N-(1-benzyloxycarbonylcyclohexyl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine in 40 ml of dioxan is hydrogenated with the addition of 0.5 g of Pd/C (10%) and worked up, in a manner analogous to that described in Example 73. The N-(1-carboxycyclohexyl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine is thus obtained in the form of colourless crystals (from ethyl acetate) melting between 134° and 136°.

Sources & evidence

ORD record
ord-2eb2581a2efa404ea5761e1c4d4aa0be
Source dataset
uspto-grants-1995_03
Patent number
US05399578

Reaction notes

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