Hydroxyamine hydrochloride → HCID 73658848, compound

HRID 1609226Notes

Reaction equation

HRID 1609226 reaction equation
[CH:1]1([C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]3[CH:26]=[CH:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[N:18]=3)=[CH:11][CH:10]=2)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:28][OH:29]>C(O)C.N1C=CC=CC=1>[CH:1]1([C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]3[CH:26]=[CH:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[N:18]=3)=[CH:11][CH:10]=2)=[N:28][OH:29])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 20084223HCID 20084223, compound

Product 1

HCID 73658848HCID 73658848, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1049PyridineSolvent

Procedure

A solution of 15.9 g (46 mmol) of 4-(quinolin-2-yl-methoxy)phenyl cyclohexyl ketone in 100 ml of ethanol and 33 ml of pyridine is stirred at room temperature for 18 h after addition of 4.77 g (68.6 mmol) of hydroxylamine hydrochloride. For working up, the mixture is concentrated in vacuo and the residue is taken up in dichloromethane. The organic phase is washed with water, dried over sodium sulphate and concentrated to dryness in vacuo.

Workup

  1. concentrationthe mixture is concentrated in vacuo
  2. washThe organic phase is washed with water
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-9f7a324649504600921e110d9b6b3722
Source dataset
uspto-grants-1995_03
Patent number
US05399698

Reaction notes

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