Paeonol → HCID 10085417, compound

HRID 1609238Notes

Reaction equation

HRID 1609238 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=1[OH:12])=[O:3].[Cl:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=O>>[Cl:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]1[O:12][C:5]2[CH:6]=[C:7]([O:10][CH3:11])[CH:8]=[CH:9][C:4]=2[C:2](=[O:3])[CH:1]=1

Participants

3

Reactant 2

HCID 11092PaeonolHCID 691102-Chlorobenzoyl chloride

Product 1

HCID 10085417HCID 10085417, compound

Procedure

2 is prepared from 2-hydroxy-4-methoxyacetophenone and 2-chlorobenzoyl chloride by the procedure of Example 1. Material is purified by flash chromatography (gradient elution using 25% ethyl acetate in hexane and 10% ethyl acetate in chloroform; material is loaded on column in methylene chloride), yielding 2 with a melting point of 148.5°-149.5° C.

Workup

  1. customMaterial is purified by flash chromatography (gradient elution using 25% ethyl acetate in hexane and 10% ethyl acetate in chloroform; material is loaded on column in methylene chloride)
  2. customyielding 2 with a melting point of 148.5°-149.5° C.

Sources & evidence

ORD record
ord-70ace0029b044108ad4bd4b9faa27457
Source dataset
uspto-grants-1995_03
Patent number
US05399584

Reaction notes

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