4-(Trifluoromethyl)benzoyl chloride → HCID 9973279, compound

HRID 1609239Notes

Reaction equation

HRID 1609239 reaction equation
[CH3:1][C:2]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:5]=1O)=[O:3].[F:13][C:14]([F:25])([F:24])[C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:23]=[CH:22][C:18]([C:19]2[O:20][C:5]3[CH:6]=[CH:7][CH:8]=[C:9]([O:10][CH3:11])[C:4]=3[C:2](=[O:3])[CH:1]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 697091-(2-Hydroxy-6-methoxyphenyl)ethan-1-one

Product 1

HCID 9973279HCID 9973279, compound

Procedure

3 is prepared from 2-hydroxy-6-methoxyacetophenone and 4-trifluoromethylbenzoyl chloride by the procedure of Example 1. The material is purified by flash chromatography (gradient elution using 25% ethyl acetate in hexane, 40% ethyl acetate in hexane, 60% ethyl acetate in hexane; material is loaded on column in methylene chloride), yielding 3 with a melting point of 190°-191° C.

Workup

  1. customThe material is purified by flash chromatography (gradient elution using 25% ethyl acetate in hexane, 40% ethyl acetate in hexane, 60% ethyl acetate in hexane; material is loaded on column in methylene chloride)
  2. customyielding 3 with a melting point of 190°-191° C.

Sources & evidence

ORD record
ord-2e10d5a334094e80a60503a62781eda1
Source dataset
uspto-grants-1995_03
Patent number
US05399584

Reaction notes

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