反应详情

温度

100 °C

To 150 ml of dimethyl sulfoxide were added 19.9 g of 3-methoxyphenol and 9.1 g of potassium hydroxide and the mixture was heated to 70°-80° C. to prepare a homogeneous solution. To this solution was added 21.1 g of 2-chloronitrobenzene and the mixture was stirred at 100° C. for 4 hours. The reaction mixture was then diluted with water and extracted with ether and the ether extract was washed succesively with 10% sodium hydroxide solution and saturated sodium chloride solution. The washed extract was dried over magnesium sulfate and the ether was distilled off to give 31.9 g of the title compound as a light yellow solid.

1. temperaturethe mixture was heated to 70°-80° C.
2. customto prepare a homogeneous solution
3. extractionextracted with ether
4. extractionthe ether extract
5. washwas washed succesively with 10% sodium hydroxide solution and saturated sodium chloride solution
6. extractionThe washed extract
7. dry with materialwas dried over magnesium sulfate
8. distillationthe ether was distilled off