反应详情

In a mixture of 12 ml of pyridine and 35 ml of dioxane was suspended 4.55 g of 2-[3-(2-nitrophenoxy)phenoxy]propionamide and, then, 3.6 g of trifluoroacetic anhydride was added dropwise with ice-cooling and stirring. The mixture was then stirred at that temperature for 30 minutes and, following addition of ice-water, extracted with ether. The ether extract was washed with diluted hydrochloric acid and sodium hydrogen carbonate solution in that order, dried and concentrated to give 4.3 g of the title compound as a light yellow oil.

1. temperaturecooling
2. stirringThe mixture was then stirred at that temperature for 30 minutes
3. extractionextracted with ether
4. extractionThe ether extract
5. washwas washed with diluted hydrochloric acid and sodium hydrogen carbonate solution in that order
6. customdried
7. concentrationconcentrated