Sodium Hydroxide → HCID 20084552, compound

HRID 1609288Notes

Reaction equation

HRID 1609288 reaction equation
[CH3:1][N:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[C:18]#[N:19])C(=O)C(F)(F)F.[OH-].[Na+]>C(O)C>[CH3:1][NH:2][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[C:18]#[N:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20084491HCID 20084491, compound

Product 1

HCID 20084552HCID 20084552, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 20 ml of ethanol was suspended 2.8 g of 2-[2-(N-methyl-N-trifluoroacetylamino)phenylthio]benzonitrile followed by addition of 4 ml of 10% aqueous sodium hydroxide solution, and the mixture was heated on a water bath for 5 minutes. After cooling, the crystals were collected by filtration and washed with 50% aqueous ethanol to give 1.8 g of the title compound as white crystals.

Workup

  1. temperaturethe mixture was heated on a water bath for 5 minutes
  2. temperatureAfter cooling
  3. filtrationthe crystals were collected by filtration
  4. washwashed with 50% aqueous ethanol

Sources & evidence

ORD record
ord-eb040bceb4f64ce58f131bdc9259274a
Source dataset
uspto-grants-1995_03
Patent number
US05399703

Reaction notes

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