Pyrrolidine → 1-[(4-Bromo-2-fluorophenyl)carbonyl]pyrrolidine

HRID 16093Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 3026814-Bromo-2-fluorobenzoic acid

Product 1

HCID 247106011-[(4-Bromo-2-fluorophenyl)carbonyl]pyrrolidine

Procedure

The sub-title compound was prepared by the method of example 18 step a) using 4-bromo-2-fluoro-benzoic acid and pyrrolidine.)

Sources & evidence

ORD record: ord-ec04af704dab4af0a800e52e05e90ec9
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07737135B2

Reaction notes

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