Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 1609408Notes

Reaction equation

HRID 1609408 reaction equation
[CH:1]1([N:7]=[C:8]=[N:9][CH:10]2[CH2:15][CH2:14][CH2:13]CC2)CCCCC1.CO.Cl[CH2:19]Cl>ClCCl>[CH3:19][N:7]([C:8]1[CH:13]=[CH:14][CH:15]=[CH:10][N:9]=1)[CH3:1]

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 21226129Dichloromethane methanol

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 23 was dissolved in dichloromethane (c. 3 mg/ml) and was treated with dicyclohexylcarbodiimide (5 equivalents), a catalytic amount of dimethylaminopyridine, and compound 11 to give after chromatography (silica, 10% methanol/dichloromethane) compound 24.

Sources & evidence

ORD record
ord-fdfa2fd778b240ee918336f7fb3265eb
Source dataset
uspto-grants-1995_03
Patent number
US05401378

Reaction notes

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