Pyridine → HCID 20081443, compound

HRID 1609442Notes

Reaction equation

HRID 1609442 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([NH:15][S:16]([CH:19]([CH:24]([CH3:26])[CH3:25])[C:20]([O:22][CH3:23])=[O:21])(=[O:18])=[O:17])[N:8]=1.N1C=CC=CC=1>ClCCl>[CH3:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([N:15]([C:1](=[O:3])[CH3:2])[S:16]([CH:19]([CH:24]([CH3:26])[CH3:25])[C:20]([O:22][CH3:23])=[O:21])(=[O:18])=[O:17])[N:8]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 20081442HCID 20081442, compound

Product 1

HCID 20081443HCID 20081443, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride (0.35 g) was added to a stirred, cooled mixture of the product of Example 1 (1.5 g) and pyridine (0.39 g) in dichloromethane (20 ml). Stirring was continued for 2 hours and the mixture was allowed to stand overnight. The organic solution was washed with water (twice), dried over magnesium sulfate and run down under vacuum. The residue was triturated with ether to yield a white solid, 0.38 g (23%), mp 100°-101.5° C.

Workup

  1. temperaturecooled
  2. waitto stand overnight
  3. washThe organic solution was washed with water (twice),
  4. dry with materialdried over magnesium sulfate
  5. customThe residue was triturated with ether
  6. customto yield a white solid, 0.38 g (23%), mp 100°-101.5° C.

Sources & evidence

ORD record
ord-220bc752afe74fc7b583ca1d56c290cc
Source dataset
uspto-grants-1995_03
Patent number
US05401710

Reaction notes

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