反应详情

温度

0 °C

To a suspension of 136 mg of sodium hydride (about 60%) in 7 ml of dimethylformamide chilled at 0° C. was added 820 mg of 2-acetoxymethyl-5-methoxy-N-(3-pyridylmethyl) benzamide and the resultant mixture was stirred at room temperature for 2 hours. The reaction mixture was mixed with water and shaken with toluene. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated in vacuo. The resultant residue was chromatographed on a column of silica gel, eluting with ethyl acetate to give 386 mg of the titled compound.

1. washThe organic layer was washed with water
2. dry with materialdried over anhydrous magnesium sulfate
3. concentrationconcentrated in vacuo
4. customThe resultant residue was chromatographed on a column of silica gel
5. washeluting with ethyl acetate