Acetic Acid → HCID 9825493, compound

HRID 1609605Notes

Reaction equation

HRID 1609605 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:27]([F:30])([F:29])[F:28])=[N:10][N:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([S:19][CH3:20])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.C(O)(=[O:33])C.OO.[OH2:37]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:27]([F:28])([F:29])[F:30])=[N:10][N:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12]=2[C:13]2[CH:14]=[CH:15][C:16]([S:19]([CH3:20])(=[O:33])=[O:37])=[CH:17][CH:18]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 962WaterHCID 15233411HCID 15233411, compound

Product 1

HCID 9825493HCID 9825493, compound

Procedure

To a mixture of 140 mg of 4-(4-fluorophenyl)-5-[4-(methylthio)phenyl]1-phenyl-3(trifluoromethyl)pyrazole and 30 mL of glacial acetic acid was added 4.1 g of 30% hydrogen peroxide. The reaction mixture was stirred at room temperature for 18 hours, heated at 80° C. for 8 hours, and poured into water. The insoluble solid was filtered and air dried to give 150 mg of solid, mp 201.5°-203° C.

Workup

  1. temperatureheated at 80° C. for 8 hours
  2. filtrationThe insoluble solid was filtered
  3. customair dried

Sources & evidence

ORD record
ord-abe87dc6dd7e47388bf7d6a47444b814
Source dataset
uspto-grants-1995_03
Patent number
US05401765

Reaction notes

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