L-Aspartic Acid → HCID 9837063, compound

HRID 1609606Notes

Reaction equation

HRID 1609606 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:19].C([O-])(=O)C>CO>[Zn:19].[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 5960L-Aspartic AcidHCID 2724192Zinc acetate (USP)HCID 10942334Sodium Methoxide

Product 1

HCID 9837063HCID 9837063, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

L-aspartic acid (2.00 g, 15.0 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.69 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (3.30 g) was then gradually dropwise added thereto at room temperature. After stirring for 2 hours at that same temperature, the precipitated crystal (in suspension) was recovered by filtration, washed with water, air dried, and then dried under a reduced pressure (5 mmHg, 80° C.).

Workup

  1. customat room temperature
  2. stirringAfter stirring for 2 hours at that same temperature
  3. filtrationthe precipitated crystal (in suspension) was recovered by filtration
  4. washwashed with water, air
  5. customdried
  6. customdried under a reduced pressure (5 mmHg, 80° C.)

Sources & evidence

ORD record
ord-e6f30b6fad7145ef890fb02ee6e81742
Source dataset
uspto-grants-1995_03
Patent number
US05401770

Reaction notes

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