L-Glutamic Acid → HCID 86605461, compound

HRID 1609607Notes

Reaction equation

HRID 1609607 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:20].C([O-])(=O)C>CO>[Zn:20].[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 33032L-Glutamic AcidHCID 2724192Zinc acetate (USP)HCID 10942334Sodium Methoxide

Product 1

HCID 86605461HCID 86605461, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

L-glutamic acid (2.0 g, 13.6 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.31 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (1.49 g) was then slowly dropwise added thereto. After refluxing and stirring for 5 hours, the precipitated crystal (in suspension) was recovered by filtration, washed with water, air dried, and then dried under a reduced pressure (5 mmHg, 80° C.).

Workup

  1. temperatureAfter refluxing
  2. stirringstirring for 5 hours
  3. filtrationthe precipitated crystal (in suspension) was recovered by filtration
  4. washwashed with water, air
  5. customdried
  6. customdried under a reduced pressure (5 mmHg, 80° C.)

Sources & evidence

ORD record
ord-1e80071257804e5387d248583bc5148b
Source dataset
uspto-grants-1995_03
Patent number
US05401770

Reaction notes

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