L-Valine → HCID 86748589, compound

HRID 1609608Notes

Reaction equation

HRID 1609608 reaction equation
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4].C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:18].C([O-])(=O)C>CO>[Zn:18].[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4]

Participants

5

Reactant 3

HCID 6287L-ValineHCID 2724192Zinc acetate (USP)HCID 10942334Sodium Methoxide

Product 1

HCID 86748589HCID 86748589, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

L-valine (2.00 g, 17.1 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.39 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (1.90 g) was then slowly dropwise added thereto at room temperature. After stirring for 6 hours at that same temperature, the precipitated crystal (in suspension) recovered by filtration, washed with water, air dried, and then dried under a reduced pressure (5 mmHg, 80° C.).

Workup

  1. customat room temperature
  2. stirringAfter stirring for 6 hours at that same temperature
  3. filtrationthe precipitated crystal (in suspension) recovered by filtration
  4. washwashed with water, air
  5. customdried
  6. customdried under a reduced pressure (5 mmHg, 80° C.)

Sources & evidence

ORD record
ord-3be2ca77e4b141b59c1e8e176b637868
Source dataset
uspto-grants-1995_03
Patent number
US05401770

Reaction notes

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