Zinc acetate (USP) → HCID 178511812, compound

HRID 1609610Notes

Reaction equation

HRID 1609610 reaction equation
[NH2:1][C@H:2]([C:9]([OH:11])=[O:10])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1.C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:21].C([O-])(=O)C>CO>[Zn:21].[NH2:1][C@H:2]([C:9]([OH:11])=[O:10])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1

Participants

5

Reactant 3

HCID 2724192Zinc acetate (USP)HCID 10942334Sodium MethoxideHCID 178419078HCID 178419078, compound

Product 1

HCID 178511812HCID 178511812, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

L-histidine (2.00 g, 12.8 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.30 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (1.41 g) was then slowly dropwise added thereto at room temperature. After stirring for 3 hours, the precipitated crystal (in suspension) was recovered by filtration, washed with water, air dried, and then concentrated under a reduced pressure (5 mmHg, 80° C.).

Workup

  1. customat room temperature
  2. stirringAfter stirring for 3 hours
  3. filtrationthe precipitated crystal (in suspension) was recovered by filtration
  4. washwashed with water, air
  5. customdried
  6. concentrationconcentrated under a reduced pressure (5 mmHg, 80° C.)

Sources & evidence

ORD record
ord-135df350313d44fa94bb63865ef18f63
Source dataset
uspto-grants-1995_03
Patent number
US05401770

Reaction notes

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