L-Phenylalanine → HCID 66996791, compound

HRID 1609611Notes

Reaction equation

HRID 1609611 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:22].C([O-])(=O)C>CO>[Zn:22].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6140L-PhenylalanineHCID 2724192Zinc acetate (USP)HCID 10942334Sodium Methoxide

Product 1

HCID 66996791HCID 66996791, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

L-phenylalanine (2.00 g, 12.1 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.30 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (1.30 g) was then slowly dropwise added thereto at room temperature. After stirring for 3 hours, the precipitated crystal (in suspension) was recovered by filtration, washed with water, air dried, and then dried under a reduced pressure (5 mmHg, 80° C.).

Workup

  1. customat room temperature
  2. stirringAfter stirring for 3 hours
  3. filtrationthe precipitated crystal (in suspension) was recovered by filtration
  4. washwashed with water, air
  5. customdried
  6. customdried under a reduced pressure (5 mmHg, 80° C.)

Sources & evidence

ORD record
ord-dd2bfa98cc114c299fb86288ccc64d36
Source dataset
uspto-grants-1995_03
Patent number
US05401770

Reaction notes

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