HCID 18648568, compound → HCID 53977342, compound

HRID 1609616Notes

Reaction equation

HRID 1609616 reaction equation
[C:1]([CH:6]([NH:20][C@H:21]([C:23]([CH:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH:27]([C:35]([OH:37])=[O:36])[NH:26]1)=[O:24])[CH3:22])[CH2:7][CH2:8][NH:9]C(OCC1C=CC=CC=1)=O)([O:3][CH2:4][CH3:5])=[O:2]>CO.[Pd]>[C:1]([CH:6]([NH:20][C@H:21]([C:23]([CH:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH:27]([C:35]([OH:37])=[O:36])[NH:26]1)=[O:24])[CH3:22])[CH2:7][CH2:8][NH2:9])([O:3][CH2:4][CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 18648568HCID 18648568, compound

Product 1

HCID 53977342HCID 53977342, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.1 g of N-(1-carboethoxy-3-benzoxycarbonylaminopropyl)-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid are dissolved in 150 ml of methanol and are hydrogenated in the presence of 100 mg of palladium/active charcoal (10% strength) at 40° C. under normal pressure. After the end of the reaction, the solution is filtered off from the catalyst and the solvent is stripped off in vacuo. Yield: 0.79 g

Workup

  1. customAfter the end of the reaction
  2. filtrationthe solution is filtered off from the catalyst

Sources & evidence

ORD record
ord-14303befa9334bc396bd7646b1c949a4
Source dataset
uspto-grants-1995_03
Patent number
US05401766

Reaction notes

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