HCID 88360535, compound → HCID 136447519, compound

HRID 1609693Notes

Reaction equation

HRID 1609693 reaction equation
[H][H].C([O:10][C:11]1[C:12]([O:30]CC2C=CC=CC=2)=[CH:13][C:14]2[C:15](=[N:22][O:23][CH2:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[CH:16]3[CH2:21][CH:17]3[O:18][C:19]=2[CH:20]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[OH:10][C:11]1[C:12]([OH:30])=[CH:13][C:14]2[C:15](=[N:22][O:23][CH2:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[CH:16]3[CH2:21][CH:17]3[O:18][C:19]=2[CH:20]=1

Participants

5

Reactant 2

HCID 88360535HCID 88360535, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 136447519HCID 136447519, compoundYield 45.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In 20 ml of ethyl acetate was suspended 48 mg of 10% palladium-on-carbon. After displacing the atmosphere with hydrogen by suction, 240 mg of the compound obtained in Example 11 was added to the suspension, and the mixture was stirred at room temperature for 5 hours in a hydrogen stream (atmospheric pressure). The reaction mixture was worked-up in the same manner as in Example 2 to obtain 67.0 mg (41.5%) of the titled compound.

Workup

  1. additionwas added to the suspension

Sources & evidence

ORD record
ord-8b421e36a9784a95a945c135f55f268a
Source dataset
uspto-grants-1995_03
Patent number
US05401850

Reaction notes

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