Tetrahydrofuran → HCID 178524980, compound

Participants

Reaction Steps

A mixture of 10 g (9.6 mmol) 1,4-O-dicarbotrichloroethoxy-3-O-dicarbotrichloroethoxycaffeoyl quinide is stirred for 5 days at ambient temperature in 65 ml THF and 8 ml concentrated HCl. After separation of the THF and saturation with NaCl, the aqueous phase is extracted with 3×40 ml ethyl acetate. The combined extracts are then washed with brine and dried over sodium sulfate and the solvent is evaporated. Treatment of the residue with a mixture of 1 volume dichloromethane to 10 volumes hexane gives 9.5 g 1,4-O-dicarbotrichloroethoxy-3-O-dicarbotrichloroethoxycaffeoyl quinic acid (yield 93%) in the form of an amorphous solid.

Provenance & Evidence