反应详情

A mixture of 10 g (9.6 mmol) 1,4-O-dicarbotrichloroethoxy-3-O-dicarbotrichloroethoxycaffeoyl quinide is stirred for 5 days at ambient temperature in 65 ml THF and 8 ml concentrated HCl. After separation of the THF and saturation with NaCl, the aqueous phase is extracted with 3×40 ml ethyl acetate. The combined extracts are then washed with brine and dried over sodium sulfate and the solvent is evaporated. Treatment of the residue with a mixture of 1 volume dichloromethane to 10 volumes hexane gives 9.5 g 1,4-O-dicarbotrichloroethoxy-3-O-dicarbotrichloroethoxycaffeoyl quinic acid (yield 93%) in the form of an amorphous solid.

1. customAfter separation of the THF and saturation with NaCl
2. extractionthe aqueous phase is extracted with 3×40 ml ethyl acetate
3. washThe combined extracts are then washed with brine
4. dry with materialdried over sodium sulfate
5. customthe solvent is evaporated
6. additionTreatment of the residue with a mixture of 1 volume dichloromethane to 10 volumes hexane