反应详情

To a solution of 2-butanol (0.92 mL, 10 mmol) and 4-methylmorpholine (1.1 mL, 10 mmol) in CHCl3 (20 mL) at -70° C. is added 7c (1.7 g, 10 mmol) during 20 min with stirring. The temperature is kept at -70° C. for 1 h and then raised (1 h) to room temperature. Next day following evaporation the residue is triturated with Et2O (25 mL) and filtered. The filtrate is evaporated and distilled to give 1.0 g (50%) of the title compound with bp 66°-68° C./5 mbar.

1. customevaporation the residue
2. customis triturated with Et2O (25 mL)
3. filtrationfiltered
4. customThe filtrate is evaporated
5. distillationdistilled