Methylamine → HCID 19429849, compound

HRID 1609775Notes

Reaction equation

HRID 1609775 reaction equation
C[O:2][C:3](=O)/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=1)=[N:5]\[O:6][CH3:7].[CH3:23][NH2:24]>>[CH3:23][NH:24][C:3](=[O:2])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=1)=[N:5]\[O:6][CH3:7]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 15764703HCID 15764703, compound

Product 1

HCID 19429849HCID 19429849, compound

Procedure

To Product (A') (286 mg), i.e. methyl-(Z)-2-[ 2- (3-tolyloxy) phenyl]-2-methoxyiminoacetate, 30% methanolic methylamine (197 mg) was added, followed by stirring at room temperature for 12 hours. Excess amine and methanol were removed from the mixture, which was subjected to silica gel column chromatography with a mixture of hexane and ethyl acetate to give 201 mg of (Z) -N-methyl-2-[2-(3-tolyloxy)phenyl]-2-methoxyiminoacetamide (Compound No. 5).

Workup

  1. customExcess amine and methanol were removed from the mixture, which
  2. additionwas subjected to silica gel column chromatography with a mixture of hexane and ethyl acetate

Sources & evidence

ORD record
ord-5201ea56d92a4d889a6fc97be7b7637a
Source dataset
uspto-grants-1995_03
Patent number
US05401877

Reaction notes

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