HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-Chloro-2-chloromethyl-5-methoxy-pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloro-5-methoxy-2-pyrazinemethanol | HCID 22260387 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloro-2-chloromethyl-5-methoxy-pyrazine | HCID 22260377 | — |
Reaction Steps
To a solution of (3-chloro-5-methoxy-pyrazin-2-yl)-methanol (100 mg, 0.57 mmol) in DCM (5 mL) was added SOCl2 (5 eq) at room temperature. The mixture is stirred at room temperature for an additional one hour. Solvent and volatile materials are removed in vacuo to dryness to give 110 mg of 3-chloro-2-chloromethyl-5-methoxy-pyrazine as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06982268B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-1909967bf9094e34aee28c05ecd39fd7 |
| Source note | uspto-grants-2006_01 |