Ethanol → Hydrogenmaleate

HRID 1609886Notes

Reaction equation

HRID 1609886 reaction equation
CN([C@@H:4]1CC2C(=CC=CC=2)[C@H:5]1[OH:13])N.[C:14]([OH:21])(=[O:20])/[CH:15]=[CH:16]\[C:17]([OH:19])=[O:18].CC[OH:24]>CCOCC>[CH2:5]([OH:13])[CH2:4][O:18][C:17]([CH2:16][CH:15]([OH:24])[C:14]([OH:21])=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 702EthanolHCID 444266Maleic AcidHCID 9857292(1r,2r)-2-(1-Methylhydrazino)-1-indanol

Product 1

HCID 87460142Hydrogenmaleate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

(1R,2R)-2-(1-methylhydrazino)-1-indanol (1.45 g, 8.1 mmol, prepared from (1R,2R)-2-methylamino-1-indanol (1.63 g, 10 mmol) according to Example 1) was treated with an equivalent amount of maleic acid in a mixture of EtOH and Et2O to give crystalline hydrogenmaleate salt which was filtered off and recrystallized.

Sources & evidence

ORD record
ord-07c6fb5e639c43e5a2d031433f9a75b8
Source dataset
uspto-grants-2006_01
Patent number
US06982286B2

Reaction notes

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