Diethyl (ethoxymethylene)malonate → HCID 12433735, compound

HRID 1609899Notes

Reaction equation

HRID 1609899 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2].CCO[CH:18]=[C:19]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[CH2:23]([O:22][C:20](=[O:21])[C:19](=[CH:18][N:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:14])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH3:24]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 80908N-Benzylglycine ethyl ester

Product 1

HCID 12433735HCID 12433735, compound

Conditions

Temperature
120 °C

Procedure

N-benzylglycine ethyl ester (5.79 g, 30 mmol) was combined with diethyl ethoxymethylene malonate (6.48 g, 30 mmol) and stirred at 120° C. for 1 hr. The crude material was used directly for the next reaction.

Sources & evidence

ORD record
ord-78d83bfedddb47619fee5f6db58e2553
Source dataset
uspto-grants-2006_01
Patent number
US06982265B1

Reaction notes

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