HCID 23590020, compound → HCID 23590017, compound

HRID 1609928Notes

Reaction equation

HRID 1609928 reaction equation
[CH2:1]([O:3][C:4](=[O:38])[C:5]([CH3:37])([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][C:17]2[N:18]=[C:19]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]#[C:30]C4C=CC=CC=4)[CH:24]=3)[O:20][C:21]=2[CH3:22])=[CH:10][CH:9]=1)[CH3:6])[CH3:2]>CCOC(C)=O>[CH2:1]([O:3][C:4](=[O:38])[C:5]([O:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][CH2:16][C:17]2[N:18]=[C:19]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]#[CH:30])[CH:24]=3)[O:20][C:21]=2[CH3:22])=[CH:12][CH:13]=1)([CH3:6])[CH3:37])[CH3:2]

Participants

3

Reactant 1

HCID 23590020HCID 23590020, compound

Product 1

HCID 23590017HCID 23590017, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Methyl-2-(4-{2-[5-methyl-2-(3-phenylethynylphenyl)oxazol-4-yl]ethoxy)phenoxy)propionic acid ethyl ester Rf=0.46 in 1:4 EtOAc:hexanes; 1H NMR (400 MHz, CDCl3) δ 8.14 (s, 1H), 7.90 (d, 1H), 7.53-7.49 (m, 3H), 7.40-7.28 (m, 4H), 6.81-6.72 (m, 4H), 4.21-4.14 (m, 4H), 2.93 (t, 2H), 2.32 (s, 3H), 1.48 (s, 6H), 1.23 (t, 3H); MS (EI) 532.2 (M+Na)+, 510.2 (M+H)+.

Sources & evidence

ORD record
ord-76737fb47cd141818fae18428cf56bb1
Source dataset
uspto-grants-2006_01
Patent number
US06982278B2

Reaction notes

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