Tetrahydrofuran → 4-Chloro-6-ethynylthieno[3,2-d]pyrimidine

HRID 160997Notes

Reaction equation

HRID 160997 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:18][CH2:19][CH2:20][CH2:21][N+:22]([CH2:23][CH2:24][CH2:25][CH3:26])([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:31][CH2:32][CH2:33][CH3:34].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[cH:8][c:9]([C:11]#[C:12][Si:13]([CH3:14])([CH3:15])[CH3:16])[s:10]2.[F-:17]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[cH:8][c:9]([C:11]#[CH:12])[s:10]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 858432224-Chloro-6-trimethylsilanylethynyl-thieno[3,2-d]pyrimidine

Product 1

HCID 599822624-Chloro-6-ethynylthieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-1aaf82fc2b17464d9a86b0030397926b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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