4-Methylmorpholine → HCID 86585199, compound

HRID 1610000Notes

Reaction equation

HRID 1610000 reaction equation
Cl.[C:2]([C:4]1([NH:10][C:11]([CH:13]([NH:19][C:20]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])[CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:12])[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)#[N:3].[N:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][N:35]=[C:36]=[O:37])[CH:29]=1.CN1CCOCC1>C(Cl)Cl>[C:2]([C:4]1([NH:10][C:11]([CH:13]([NH:19][C:20]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)=[O:21])[CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:12])[CH2:5][CH2:6][N:7]([C:36](=[O:37])[NH:35][CH2:34][C:30]2[CH:29]=[N:28][CH:33]=[CH:32][CH:31]=2)[CH2:8][CH2:9]1)#[N:3]

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 154546703-(Isocyanatomethyl)pyridineHCID 22260424HCID 22260424, compound

Product 1

HCID 86585199HCID 86585199, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared from morpholine-4-carboxylic acid[1-(4-cyano-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butyl]-amide hydrochloride and 3-pyridyl-methyl isocyanate in the presence of a tertiary amine base such as N-methylmorpholine in a solvent such as methylene chloride.

Sources & evidence

ORD record
ord-67a7623ad908427284da46a5cc8b5e84
Source dataset
uspto-grants-2006_01
Patent number
US06982272B2

Reaction notes

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