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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1610028Generated: October 25, 2026

Sodium Hydroxide → 2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acid

https://huagongshe.com/reaction/1610028

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactantethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylateHCID 17747724—
Solventtert-Butyl methyl etherHCID 15413—
Product2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acidHCID 17747725—

Reaction Steps

Ethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate is refluxed with aqueous sodium hydroxide in methyl tertiary-butyl ether (MTBE) to form 2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06982335B2
Source datasetuspto-grants-2006_01
ORD IDord-111bec30d04d46b7a66619eb713c6206
Source noteuspto-grants-2006_01