Sodium Hydroxide → 2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acid

HRID 1610028Notes

Reaction equation

HRID 1610028 reaction equation
C([O:3][C:4]([C@@H:6]1[CH2:10][S:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[O:19][CH3:20])=[N:7]1)=[O:5])C.[OH-].[Na+]>C(OC)(C)(C)C>[CH3:20][O:19][C:12]1[CH:13]=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:11]=1[C:8]1[S:9][CH2:10][C@@H:6]([C:4]([OH:5])=[O:3])[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 17747724ethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate

Product 1

HCID 177477252-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acid

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Ethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate is refluxed with aqueous sodium hydroxide in methyl tertiary-butyl ether (MTBE) to form 2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acid.

Sources & evidence

ORD record
ord-111bec30d04d46b7a66619eb713c6206
Source dataset
uspto-grants-2006_01
Patent number
US06982335B2

Reaction notes

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