Hydrochloric Acid → HCID 22260692, compound

HRID 1610108Notes

Reaction equation

HRID 1610108 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([CH:17]([OH:24])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:15]=3)[N:10](C(OC(C)(C)C)=O)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)=[O:24])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22261051HCID 22261051, compound

Product 1

HCID 22260692HCID 22260692, compoundYield 17.6%

Procedure

A total of 30 mg of tert-butyl 3-(3-fluorophenyl)-5-[hydroxy(phenyl)methyl]-1H-1-indazolecarboxylate as a starting material was oxidized by the procedure of Production Example I-4-c, was treated with 5 N hydrochloric acid by the procedure of Production Example I-25-b, to give 4 mg of the title compound as a colorless powder.

Sources & evidence

ORD record
ord-3ee717fb21784882b8bbf3007f6bb6ca
Source dataset
uspto-grants-2006_01
Patent number
US06982274B2

Reaction notes

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