Hydrochloric Acid → 2-(4-Fluorophenyl)-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]ethylamine hydrochloride

HRID 1610165Notes

Reaction equation

HRID 1610165 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:24])[CH:9]([NH:21]C=O)[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[ClH:25]>CO>[ClH:25].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:24])[CH:9]([NH2:21])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 865932142-(4-Fluorophenyl)-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]ethylformamide

Product 1

HCID 222621952-(4-Fluorophenyl)-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]ethylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(4-fluorophenyl)-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]ethylformamide (13.87 g, 40.9 mmol) in methanol (100 ml) was added conc. hydrochloric acid (3.8 ml, 45.0 mmol), and the mixture was heated under reflux for 2 hrs. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethyl acetate to give the objective substance.(13.63 g, 96%) as crystals.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2 hrs
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. washthe residue was washed with ethyl acetate
  5. customto give the objective substance

Sources & evidence

ORD record
ord-1e13c0d57049474281c0838d2e9aaeaa
Source dataset
uspto-grants-2006_01
Patent number
US06982348B2

Reaction notes

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