反应详情

To a solution of 2-methyl-5-(trifluoromethyl)furan (4 g, 26.6 mmol) in chloroform (60 ml) were added N-bromosuccinimide (5.2 g, 29.3 mmol) and 2,2′-azobis(isobutyronitrile) (220 mg, 1.33 mmol). The reaction solution was heated under reflux for 15 min. The reaction solution was cooled, poured into water (200 ml) and was extracted with chloroform. The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give 2-(bromomethyl)-5-(trifluoromethyl)furan (4.79 g, 78%).

1. temperatureThe reaction solution was heated
2. temperatureunder reflux for 15 min
3. temperatureThe reaction solution was cooled
4. extractionwas extracted with chloroform
5. washThe extract was washed with water and saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customevaporated under reduced pressure