反应详情

To 4-(pyridin-2-yloxy)benzoic acid (20 g, 92.9 mmol) in tetrahydrofuran (300 ml) was added N,N′-carbonyldiimidazole (16.6 g, 102 mmol), and the mixture was heated under reflux for 1 hr. After cooling the reaction solution to room temperature, monobenzyl malonate magnesium salt (21 g, 51.2 mmol) was added, and the mixture was heated under reflux for 2 hrs. The reaction solution was concentrated and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give the objective substance (20.6 g, 64%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hr
3. temperaturethe mixture was heated
4. temperatureunder reflux for 2 hrs
5. concentrationThe reaction solution was concentrated
6. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)
7. customto give the objective substance (20.6 g, 64%)