反应详情

To a solution of 2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxine-6-carbonitrile (5.0 g, 21.44 mmol) in acetic acid (20 ml) was added conc. hydrochloric acid (20 ml), and the mixture was heated under reflux overnight. The reaction solution was concentrated, and the precipitated crystals were filtered and washed with water to give the objective substance (4.76 g, 88%).

1. temperaturethe mixture was heated
2. temperatureunder reflux overnight
3. concentrationThe reaction solution was concentrated
4. filtrationthe precipitated crystals were filtered
5. washwashed with water
6. customto give the objective substance (4.76 g, 88%)