反应详情

温度

0 °C

To a solution of lithium aluminum hydride (1.40 g, 36.89 mmol) in tetrahydrofuran (30 ml) was gradually added 2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxine-6-carboxylic acid (4.65 g, 18.44 mmol) at 0° C. After the reaction solution was stirred at 0° C. for 10 min., 1N aqueous sodium hydroxide solution was added. Insoluble material was filtered off with celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give the objective substance (3.54 g, 81%).

1. customat 0° C
2. filtrationInsoluble material was filtered off with celite
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)
5. customto give the objective substance (3.54 g, 81%)