反应详情

To a solution of ethyl 3-isopropyloxybenzoate (12.0. g, 61.8 mmol) in tetrahydrofuran (100 ml) was added lithium aluminum hydride (3.52 g, 92.7 mmol) by small portions under ice-cooling. The mixture was stirred at room temperature for 1 hr. and water (10 ml) was added under ice-cooling to allow decomposition. Insoluble material was filtered off and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1) to give the objective substance (10.0 g, 97%) as an oil.

1. temperaturecooling
2. temperaturecooling
3. filtrationInsoluble material was filtered off
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1)
6. customto give the objective substance (10.0 g, 97%) as an oil