[[5-Chloro-3'-fluoro-4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-2-yl]oxy]-acetic acid → (2S)-2-[[3'-fluoro-4'-(1-pyrrolidinylcarbonyl)-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

HRID 16107Notes

Reaction equation

HRID 16107 reaction equation
ClC1C=CC(OCC(O)=O)=C([C:8]2[CH:13]=[CH:12][C:11]([C:14]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:15])=[C:10]([F:21])[CH:9]=2)C=1.B([C:30]1[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:31]=1[O:32][C@@H:33]([CH3:37])[C:34]([OH:36])=[O:35])(O)O>>[F:21][C:10]1[CH:9]=[C:8]([C:30]2[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:31]=2[O:32][C@@H:33]([CH3:37])[C:34]([OH:36])=[O:35])[CH:13]=[CH:12][C:11]=1[C:14]([N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:15]

Participants

3

Reactant 2

HCID 11646544[[5-Chloro-3'-fluoro-4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-2-yl]oxy]-acetic acidHCID 67277101(2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid

Product 1

HCID 11604262(2S)-2-[[3'-fluoro-4'-(1-pyrrolidinylcarbonyl)-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

Procedure

The title compound was prepared using the product of example 24 part a) and (2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid [WO2004089885] by the method of example 32 step b).

Sources & evidence

ORD record
ord-399619e7ca9440e18150c27dc8ee26a1
Source dataset
uspto-grants-2010_06
Patent number
US07737135B2

Reaction notes

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