HuagongsheHuagongshe Chemistry Print Report · For research reference only
[[5-Chloro-3'-fluoro-4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-2-yl]oxy]-acetic acid → (2S)-2-[[3'-fluoro-4'-(1-pyrrolidinylcarbonyl)-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [[5-Chloro-3'-fluoro-4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-2-yl]oxy]-acetic acid | HCID 11646544 | — |
| Reactant | (2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid | HCID 67277101 | — |
| Product | (2S)-2-[[3'-fluoro-4'-(1-pyrrolidinylcarbonyl)-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid | HCID 11604262 | — |
Reaction Steps
The title compound was prepared using the product of example 24 part a) and (2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid [WO2004089885] by the method of example 32 step b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737135B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-399619e7ca9440e18150c27dc8ee26a1 |
| Source note | uspto-grants-2010_06 |