反应详情

A solution of tert-pentylbenzene (10.04 g, 67.72 mmol) and hexamethylenetetramine (9.49 g, 67.7 mmol) in trifluoroacetic acid (100 ml) was stirred at 90° C. overnight. The reaction solution was evaporated under reduced pressure, diluted with water, alkalified with potassium carbonate, and extracted twice with ethyl acetate. The recovered organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give a crude product of 4-(tert-pentyl)benzaldehyde as a dark brown liquid.

1. customThe reaction solution was evaporated under reduced pressure
2. additiondiluted with water
3. extractionextracted twice with ethyl acetate
4. dry with materialThe recovered organic layer was dried over anhydrous sodium sulfate
5. customthe solvent was evaporated under reduced pressure