HCID 11316724, compound → 2-(1H-Benzimidazol-2-yl)-1-phenylethan-1-one

HRID 1610823Notes

Reaction equation

HRID 1610823 reaction equation
C([O:9]/[C:10](/[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[CH:11]\[C:12]1[N:16](C(=O)C2C=CC=CC=2)[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=2[N:13]=1)(=O)C1C=CC=CC=1>Cl>[NH:13]1[C:14]2[CH:28]=[CH:27][CH:26]=[CH:25][C:15]=2[N:16]=[C:12]1[CH2:11][C:10]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:9]

Participants

3

Reactant 1

HCID 11316724HCID 11316724, compound

Product 1

HCID 3500582-(1H-Benzimidazol-2-yl)-1-phenylethan-1-oneYield 152.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5.73 g (0.01 mol) of the compound of Example I are refluxed 2 h in 115 ml concentrated hydrochloric acid. The mixture is cooled to rT and concentrated under vacuum. The residue is washed with petrol ether and the product is filtered, stirred with toluene and filtered again, washed with petrol ether, filtered and dried to yield 3.6 g (96% o.th.) 2-(1H-Benzimidazol-2-yl)-1-phenylethanone.

Workup

  1. temperatureThe mixture is cooled
  2. concentrationconcentrated under vacuum
  3. washThe residue is washed with petrol ether
  4. filtrationthe product is filtered
  5. filtrationfiltered again
  6. washwashed with petrol ether
  7. filtrationfiltered
  8. customdried

Sources & evidence

ORD record
ord-f7944800c05c4451a08d735e887fa182
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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