反应详情

12.97 g crude crude compound of Example V are refluxed 1.5 h in 200 ml concentrated hydrochloric acid. The mixture is cooled to rT and 200 mL water are added. The solution is extracted twice with toluene and the aqueous phase is concentrated under vacuum. The residue is stirred with ethanol, filtered, washed once with ethyl acetate and once with petrol ether and dried to yield 1.04 g (14% of th.) 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(2-fluorophenyl)ethanone hydrochloride.

1. temperatureThe mixture is cooled
2. extractionThe solution is extracted twice with toluene
3. concentrationthe aqueous phase is concentrated under vacuum
4. filtrationfiltered
5. washwashed once with ethyl acetate and once with petrol ether
6. customdried