4-Fluorobenzoyl chloride → HCID 22258168, compound

Participants

Reaction Steps

The compound is prepared as described in example XXXXIII with 2.00 g (14.68 mmol) 2-methyl-4,5,6,7-tetrahydro-1H-benzimidazole, 6.98 g (44.05 mmol) of 4-fluorobenzoyl chloride and 4.90 g (48.42 mmol) of TEA in 50 ml acetonitrile. The crude intermediate is directly transformed into 1-(2,4-Difluorophenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)-ethanone to yield 737 mg (10.7% of th.).

Provenance & Evidence