Propiolic Acid → HCID 22258187, compound

HRID 1610849Notes

Reaction equation

HRID 1610849 reaction equation
[C:1](O)(=[O:4])[C:2]#[CH:3].N1(C(N2C=CN=C2)=O)C=CN=C1.[CH2:18]([C:20]1[N:21]=[C:22]([CH2:27][C:28]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)=[O:29])[NH:23][C:24]=1[CH2:25][CH3:26])[CH3:19]>>[CH2:25]([C:24]1[NH:23][C:22]2[N:21]([C:20]=1[CH2:18][CH3:19])[C:1](=[O:4])[CH:2]=[CH:3][C:27]=2[C:28](=[O:29])[C:30]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=1)[CH3:26]

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 22258163HCID 22258163, compound

Product 1

HCID 22258187HCID 22258187, compound

Procedure

The compound is prepared as described in example 6 with 122.1 mg (1.67 mmol) of propiolic acid, 325.6 mg (2.01 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole and 300 mg (1.12 mmol) of 2-(4,5-Diethyl-1H-imidazol-2-yl)-1-(4-fluorophenyl)ethanone (example XXVII).

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-c49bff54432e43c1bd8d50f10d2cd7c0
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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