Propiolic Acid → HCID 22258279, compound

HRID 1610850Notes

Reaction equation

HRID 1610850 reaction equation
[C:1]([OH:5])(=O)[C:2]#[CH:3].N1(C(N2C=CN=C2)=O)C=CN=C1.[CH2:18]([C:20]1[N:21]=[C:22]([CH2:27][C:28]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:31]=2[F:37])=[O:29])[NH:23][C:24]=1[CH2:25][CH3:26])[CH3:19]>>[F:37][C:31]1[CH:32]=[C:33]([F:36])[CH:34]=[CH:35][C:30]=1[C:28]([C:27]1[CH:3]=[CH:2][C:1](=[O:5])[N:23]2[C:24]([CH2:25][CH3:26])=[C:20]([CH2:18][CH3:19])[NH:21][C:22]=12)=[O:29]

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 22258167HCID 22258167, compound

Product 1

HCID 22258279HCID 22258279, compound

Procedure

The compound is prepared as described in example 6 with 98.3 mg (1.35 mmol) of propiolic acid, 262.2 mg (1.62 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole and 250 mg (0.90 mmol) of 2-(4,5-Diethyl-1H-imidazol-2-yl)-1-(2,4-difluorophenyl)ethanone (example XXVII).

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-02afc0a88c144f87a2551476e6f83e0a
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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